Traditional Medicinal Plants to Strengthen Immunity during COVID- 19: A Ray of Hope

Authors

  • Mahrukh Malik Corresponding Author, Drugs Control and Traditional Medicines Division, National Institute of Health, Islamabad, Pakistan Author
  • Kanwal Batool Quality Assurance Department, National Institute of Health, Islamabad, Pakistan Author
  • Syeda Aaliya Shehzadi Sulaiman Bin Abdullah Aba Al-Khail-Centre for Interdisciplinary Research in Basic Sciences (SA-CIRBS), International Islamic University-44000 Islamabad, Pakistan Author

DOI:

https://doi.org/10.61506/

Keywords:

Traditional Medicines, Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2), COVID- 19, Immunity booster; Antiviral, Medicinal plants

Abstract

Coronavirus disease 2019 (COVID-19) is caused by coronavirus 2 (SARS-CoV- 2). Symptoms include cough, fever, shortness of breath, pneumonia,muscle pain and multi organ failure. Via respiratory droplets the infection spreads from one person to another. For the prevention of COVID-19 alternative medicine home remedies using traditional medicinal plants, are being recommended. The aim of this systematic scoping research survey was to focus attention to have a research policy to identify, and summarize the scientific evidences promoting the use of traditional medicinal plants for the treatment of COVID-19 and for boosting immune system. By systematic planning, reduce use of high cost treatment to these low cost remedies. A comprehensive research survey was performed in two phases: phase 1 (qualitative phase) for development of a questionnaire and phase 2 (quantitative phase) for validation of the questionnaire. In addition, freewheeling searches of government health ministries and government websites was done to gain the available information. Records available until March 20, 2021 were considered. Results were summarized for prevention or treatment of COVID-19 patients in Islamabad and Rawalpindi. Screening (primary and secondary) of the records and data extraction from the eligible sources and patients were done by a single person followed by a random check by the second and third reviewers. Overall, 124 patients were identified and their data was collected. Different herbal medicinal plants were explored by different patients as home remedies in the research survey. Several herbal medicinal plants options are proposed in this research survey to collect more and more data for the prevention or treatment of COVID-19. However, their efficacy and safety still needs scientific validation through rigorous randomized controlled trials. This research may help inform decisions about the importance of research and development in traditional medicinal plants for COVID-19 prevention and treatment. Findings indicate that half of the participants (50·41%) reportedly had a stable weight followed by one-third participants (31·71%) experiencing weight gain during COVID-19. Half of the participants (50 %) maintained a regular meal pattern and added these traditional medicinal plants ingredients to their daily meals (48·39 %).

References

Ahmad, N., Fazal, H., Abbasi, B. H., Farooq, S., Ali, M., & Khan, M. A. (2012). Biological role of Piper nigrum L. (black pepper): A review. Asian Pacific Journal of Tropical Biomedicine, 2(3), S1945-S1953.

Bae, E. A., Han, M. J., & Kim, D. H. (1999). In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites. Planta Medica, 65(5), 442-443.

Benarba, B., & Pandiella, A. (2020). Medicinal plants as sources of active molecules against COVID-19. Frontiers in Pharmacology, 11, 1189.

Benzie, I. F. F., & Wachtel-Galor, S. (2011). Herbal Medicine: Biomolecular and Clinical Aspects (2nd ed.). CRC Press/Taylor & Francis.

Blankson, H., Grotterød, E. M., & Seglen, P. O. (2000). Prevention of toxin-induced cytoskeletal disruption and apoptotic liver cell death by the grapefruit flavonoid, naringin. Cell Death & Differentiation, 7(8), 739-746.

Burham, B. O. (1984). Chemical constituents of selected Sudanese medicinal and aromatic plants. Master’s Thesis, Sudan Academy of Science.

Chaurasia, J. P. (2001). Betelvine Cultivation and Management of Diseases. Scientific Publishers (India).

Chiang, L. C., Ng, L. T., Cheng, P. W., Chiang, W., & Lin, C. C. (2005). Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clinical and Experimental Pharmacology and Physiology, 32(10), 811-816.

Damle, M. (2014). Glycyrrhiza glabra (Liquorice)—A potent medicinal herb. International Journal of Herbal Medicine, 2(2), 132-136.

Felsenstein, S., & Hedrich, C. M. (2020). COVID-19 in children and young people. The Lancet Rheumatology, 2(9), e514-e516.

Folts, J. D. (2002). Potential health benefits from the flavonoids in grape products on vascular disease. Flavonoids in Cell Function, 95-111.

Forouzanfar, F., Bazzaz, B. S., & Hosseinzadeh, H. (2014). Black cumin (Nigella sativa) and its constituent (thymoquinone): A review on antimicrobial effects. Iranian Journal of Basic Medical Sciences, 17(12), 929.

Giamperi, L., Fraternale, D., Bucchini, A., & Ricci, D. (2004). Antioxidant activity of Citrus paradisi seeds glyceric extract. Fitoterapia, 75(2), 221-224.

Goothy, S. S., Goothy, S., Choudhary, A., Potey, G. G., Chakraborty, H., Kumar, A. H., & Mahadik, V. K. (2020). Ayurveda’s holistic lifestyle approach for the management of coronavirus disease (COVID-19): Possible role of Tulsi. International Journal of Research in Pharmaceutical Sciences, 16-18.

Gülçin, İ., Elmastaş, M., & Aboul-Enein, H. Y. (2012). Antioxidant activity of clove oil—A powerful antioxidant source. Arabian Journal of Chemistry, 5(4), 489-499.

Gupta, V., Kohli, K., Ghaiye, P., Bansal, P., & Lather, A. (2011). Pharmacological potentials of Citrus paradisi: An overview. International Journal of Phytotherapy Research, 1(1), 8-17.

Hossain, M. D., Urbi, Z., Sule, A., & Rahman, K. M. (2014). Andrographis paniculata (Burm. f.) Wall. ex Nees: A review of ethnobotany, phytochemistry, and pharmacology. The Scientific World Journal, 2014.

Jamshidi, N., & Cohen, M. M. (2017). The clinical efficacy and safety of Tulsi in humans: A systematic review of the literature. Evidence-Based Complementary and Alternative Medicine, 2017.

Jinu, J. (2019). Therapeutic potential of Withania somnifera: A report on phyto-pharmacological properties. International Journal of Pharmaceutical Sciences Research, 4, 2131-2148.

Joshi, D. R., Shrestha, A. C., & Adhikari, N. (2018). A review on diversified use of the king of spices: Piper nigrum (black pepper). IJPSR, 9(10), 4089-4101.

Khan, Z., Karataş, Y., Ceylan, A. F., & Rahman, H. (2021). COVID-19 and therapeutic drugs repurposing in hand: The need for collaborative efforts. Le Pharmacien Hospitalier et Clinicien, 56(1), 3-11.

Kurokawa, M., Hozumi, T., Basnet, P., Nakano, M., Kadota, S., Namba, T., Kawana, T., & Shiraki, K. (1998). Purification and characterization of eugeniin as an anti-herpesvirus compound from Geum japonicum and Syzygium aromaticum. Journal of Pharmacology and Experimental Therapeutics, 284(2), 728-735.

Mair, C. E., Liu, R., Atanasov, A. G., Schmidtke, M., Dirsch, V. M., & Rollinger, J. M. (2016). Antiviral and anti-proliferative in vitro activities of piperamides from black pepper. Planta Medica, 82(S 01), P807.

Motilva, V., De La Lastra, C. A., & Martin, M. J. (1994). Ulcer-protecting effects of naringenin on gastric lesions induced by ethanol in rats: Role of endogenous prostaglandins. Journal of Pharmacy and Pharmacology, 46(2), 91-94.

Pradhan, D., Suri, K. A., Pradhan, D. K., & Biswasroy, P. (2013). Golden heart of the nature: Piper betle L. Journal of Pharmacognosy and Phytochemistry, 1(6).

Reagor, L., Gusman, J., McCoy, L., Carino, E., & Heggers, J. P. (2002). The effectiveness of processed grapefruit-seed extract as an antibacterial agent: I. An in vitro agar assay. The Journal of Alternative & Complementary Medicine, 8(3), 325-332.

Schoeman, D., & Fielding, B. C. (2019). Coronavirus envelope protein: Current knowledge. Virology Journal, 16(1), 1-22.

Shamim Molla, M., Azad, A. K., Al Hasib, M. A., Hossain, M. M., Ahammed, M. S., Rana, S., & Islam, M. T. (2019). A review on antiviral effects of Nigella sativa L. Pharmacology Online Newsletter, 2, 47-53.

Singh, N., Rao, A. S., Nandal, A., Kumar, S., Yadav, S. S., Ganaie, S. A., & Narasimhan, B. (2021). Phytochemical and pharmacological review of Cinnamomum verum J. Presl: A versatile spice used in food and nutrition. Food Chemistry, 338, 127773.

So, F. V., Guthrie, N., Chambers, A. F., Moussa, M., & Carroll, K. K. (1996). Inhibition of human breast cancer cell proliferation and delay of mammary tumorigenesis by flavonoids and citrus juices. Nutrition and Cancer, 26, 167-181.

Srivastava, A. K., Chaurasia, J. P., Khan, R., Dhand, C., & Verma, S. (2020). Role of medicinal plants of traditional use in recuperating devastating COVID-19 situation. Medicinal & Aromatic Plants (Los Angeles), 9(359), 2167-0412.

Surana, S. J., Gokhale, S. B., Rajmane, R. A., & Jadhav, R. B. (2006). Non-saccharides natural intense sweeteners—An overview of current status. Natural Product Radiance, 5(4), 270-278.

Upadhyay, R. K. (2016). Nutraceutical, pharmaceutical, and therapeutic uses of Allium cepa: A review. International Journal of Green Pharmacy, 10(1).

Zayachkivska, O. S., Konturek, S. J., Drozdowicz, D., Konturek, P. C., Brzozowski, T., & Ghegotsky, M. R. (2005). Gastroprotective effects of flavonoids in plant extracts. Journal of Physiology and Pharmacology Supplement, 56(1), 219-231.

Zhang, D. H., Wu, K. L., Zhang, X., Deng, S. Q., & Peng, B. (2020). In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus. Journal of Integrative Medicine, 18(2), 152-158.

Downloads

Published

2024-11-15

Issue

Section

Articles

How to Cite

Malik, M. ., Batool, K. ., & Shehzadi, S. A. . (2024). Traditional Medicinal Plants to Strengthen Immunity during COVID- 19: A Ray of Hope. Bulletin of Business and Economics (BBE), 13(4), 20-26. https://doi.org/10.61506/